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The target for William, four, of Newbolt Road, Balby, was given a huge boost when an anonymous benefactor donated 35,000 half the total needed earlier this year.
She will be setting off from The Sportsman at 9am, accompanied by scores of other runners to draw in more cash.
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"People don't realise the daily struggles he has to go through, the pain he is in or how much of a challenge everything is," added Michelle, who stepped down from her job to devote 2017 Air Max Red
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her time to caring for her son.
She said: "He knows people are raising money to help make his legs better. I've told him the doctors over in America will do some special magic to help him walk and he won't be in pain and you can see what that means to him."
"It is amazing to think that in the next few months William's life will change for the better forever.
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Doncaster youngster could walk again thanks to fundraising appeal
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The countdown is now on to reach the 70,000 target needed to send Balby youngster William Moreland to the United States for a life changing operation which will allow him to walk for the very first time.
And proud mum Michelle Gale admits she has been 'overwhelmed' by people who have rushed to back the campaign to 2016 Nike Air Max White help William, who suffers from spastic quadriplegic cerebral palsy which means he cannot walk, cannot care for himself and has to use a wheelchair.
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The donation has allowed Michelle to move the date of the operation forward from next January to this October and she says her son is beginning to realise that his life could soon change for the better, thanks to the massive fundraising drive.
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The latest money spinner today will see Mexborough brain tumour survivor Donna Howley take on a 10 mile run in aid of the appeal as well as Sheffield based charity Neurocare.
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